The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Rheumatoid arthritis ra happens when your bodys defenses your immune system target the synovium, a thin layer of tissue that lines your joint. Van dellen, division of allergic diseases, mayo clinic. Ppt rheumatoid arthritis powerpoint presentation free. Psoriatic arthritis is an inflammatory disease, the manifestations of which may include. It can be mild, moderate, or severe, and symptoms vary from person to person. Swelling of the small joints, especially in the hands and feet, is the hallmark of the disease, but most joints in the body can become affected. Inflammation and thickening of the synovial membranes the sacs holding the fluid that lubricates the joints cause irreversible damage to the joint capsule and the articular joint cartilage as these structures are replaced by scarlike tissue called. Pathogenesis of rheumatoid arthritis thermo fisher. Within a framework that recognizes both immunological activation and inflammatory pathways, we can begin to evaluate the multiple components of disease initiation and propagation. Rheumatoid arthritis primarily is a clinical diagnosis. About rheumatoid arthritis powerpoint presentation. Webmd rheumatoid arthritis guide better information for.
It is a chronic, progressive, systemic inflammatory disorder affecting the synovial joints and typically producing symmetrical arthritis. In rheumatoid arthritis, however, morning stiffness doesnt begin to improve for an hour or longer. Rheumatoid arthritis ra affects more than a million people in the u. Furthermore, rheumatoid arthritis appears to be associated with periodontal disease. It is characterized by synovial inflammation and gradual bone erosion over many years, and disease progression results in stiffness and pain, especially in the hands and feet, which. Rheumatoid arthritis ra a longterm autoimmune disorder rheumatoid arthritis is one of the chronic inflammatory disorders which can affect more than just your joints. Diffuse swelling of the fingers and toes known as dactylitis.
Characteristically, peripheral joints eg, wrists, metacarpophalangeal joints are symmetrically inflamed, leading to progressive destruction of articular structures. Rheumatoid arthritis is best characterized as an immune mediated inflammatory disease imid. It fades off the color from the life of the patient. Rheumatoid arthritis, chronic, frequently progressive disease in which inflammatory changes occur throughout the connective tissues of the body. Rheumatoid arthritis ra is a chronic inflammatory disorder of the small joints of the hands and feet, in which synovial inflammation leads to joint erosion and deformity. It typically results in warm, swollen, and painful joints. Rheumatoid arthritis ra is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and. Rheumatoid arthritis is more severe than i ever really began to think that it was. Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability.
The increased understanding of the immune mechanisms of. Rheumatoid arthritis ra, one of the more common chronic inflammatory diseases, is characterized by inflammation and swelling of the synovium. Ive been a sufferer of rheumatoid arthritis for almost 11 years now. Webmd s rheumatoid arthritis guide has all the information you need to understand and selfmanage ra. Patients commonly present with pain and stiffness in multiple joints, although one third of patients initially. Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage, functional loss, and comorbidity. This helps you give your presentation on about rheumatoid arthritis in a conference, a school lecture, a business proposal. These are very important in the pathogenesis of rheumatoid arthritis. For more about diagnosing and treating rheumatoid arthritis pain, buy rheumatoid arthritis, a special health report from harvard medical school. The pathophysiology of rheumatoid arthritis powerpoint. Rheumatoid arthritis pathogenesis linkedin slideshare. Rheumatoid arthritis ra is one of the most common chronic inflammatory diseases and in modern times has become a prototype disease entity for defining the molecular and pathological basis of chronic inflammatory syndromes.
Sometimes, the condition may damage a wide variety of body systems, including the eyes, skin, lungs, heart and blood vessels. Rheumatoid arthritis ra is an autoimmune systemic disease that primarily affects joints. Rheumatoid arthritis ra affects different people in different ways. With free rheumatoid arthritis ppt presentation template you can explain your thoughts in graphical manner and gain viewer attention. Rheumatoid arthritis rheumatoid arthritis is a common auto immune disease that is associated with progressive disability, systemic complications, early death,and socioeconomic costs. The report highlights the key trends, market outlook and global drugs for rheumatoid arthritis market the global scenario of the global drugs for rheumatoid arthritis market. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. Pathogenesis, treatment response and tailored therapy. Th1 cells were originally thought to play a role in the genesis of autoimmune disease because il12 and ifn. Inflammatory arthritis which over time typically progresses to involve greater numbers of joints and can result in joint damage in over 40% of patients. Etiology and the pathogenesis of ra are complex, involving many types of cells, among others macrophages, t and b cells, fibro blasts, chondrocytes and. The development of effective biologics and smallmolecule kinase inhibitors in the past two decades has substantially improved clinical outcomes. The hallmark feature of this condition is persistent symmetric polyarthritis synovitis that affects the hands and feet, though any joint lined by a synovial membrane may be involved.
The pathogenesis of rheumatoid arthritis list of authors. Rheumatoid arthritis ra is a longterm autoimmune disorder that primarily affects joints. Rheumatoid arthritis ra is a chronic systemic inflammatory disease of unknown cause. Rheumatoid arthritis pathophysiology ra pathophysiology. If left untreated, it leads to joint destruction, which is responsible for. Rheumatoid arthritis ra is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. Drugs for rheumatoid arthritis market is expected to grow at cagr of 6. Women, smokers, and those with a family history of the disease are most often affected. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of.
It is designed by professional designers to make your upcoming presentation attractive. Review indepth clinical information, latest medical news, and guidelines on rheumatoid arthritis. I watched my grandmother suffer through it for so many years, but never really understood the extent of the disease. The aetiology and pathogenesis of rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathwaysmechanisms, and genetic and environmental factors that instigate and drive the disease. Rheumatoid arthritis an overview sciencedirect topics. Rheumatoid arthritis ra is the most common inflammatory arthritis, affecting approximately 1 percent of the population. Rheumatoid arthritis or ra is a form of inflammatory polyarthritis that can lead to joint destruction, deformity, and loss of function. The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. Rheumatoid arthritis ra musculoskeletal and connective.
This also leads to bone and cartilage erosion breakdown. Early diagnosis is key to optimal therapeutic success, particularly in patients with wellcharacterised risk factors for poor outcomes such as high disease activity, presence of autoantibodies, and early joint damage. Rheumatoid arthritis market to 2020 a crowded market characterized by modest growth rheumatoid arthritis ra is a chronic, progressive and currently incurable autoimmune disease that primarily affects joints. The new england journal of medicine n engl j med 365.
Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis. Rheumatoid arthritis ra is one of the commonest autoimmune diseases. Porphyromonas gingivalis expresses padi4, which is capable of promoting citrullination of mammalian proteins. Pathogenetic insights from the treatment of rheumatoid.
Ra is an autoimmune disease of unknown aetiology that primarily targets synovial tissues, cartilage and bone, and is the most common form of immunemediated arthritis. Occasionally, prolonged joint stiffness in the morning is the first symptom of rheumatoid arthritis. Introduction ra is a chronic systemic autoimmune disorder causing a symmetrical polyarthritis. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, search for articles by this author correspondence. Powerpoint is the worlds most popular presentation software which can let you create professional about rheumatoid arthritis powerpoint presentation easily and in no time. Ra causes damage mediated by cytokines, chemokines, and metalloproteases. Under these experimental conditions, interventions that disrupt this quaternary complex eg, rheumatoid arthritis. Epidemiology, pathophysiology, and diagnosis of rheumatoid.
Explain the pain is it osteoarthritis or rheumatoid. It is an autoimmune condition which predominantly affects joints and has systemic extraarticular manifestations as well. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. The disease may also affect other parts of the body. Although the armamentarium of therapies to treat ra is extensive, optimal symptom control and management of the disease have been elusive. Freetemplatestheme presents rheumatoid arthritis powerpoint template for free with high quality design. Just as understanding of pathogenesis has led in large part to the development of drugs, so have modeofaction studies. The synovial membrane is made up of these cells known as fibroblastlike synoviocytes fls. Rheumatoid arthritis ra is a chronic systemic autoimmune disease that primarily involves the joints.
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